top of page

Belzutifan/MK-6482 in PNET + PPGL + VHL

Belzutifan/MK-6482 for the Treatment of Advanced Pheochromocytoma/Paraganglioma (PPGL), Pancreatic Neuroendocrine Tumor (pNET), Von Hippel-Lindau (VHL) Disease-Associated Tumors, Advanced Gastrointestinal Stromal Tumor (wt GIST), or Solid Tumors With HIF-2α Related Genetic Alterations (MK-6482-015)


DRUG/TREATMENT: Oral Treatment: Belzutifan 


STATUS: Recruiting

SPONSOR: Merck Sharp & Dohme LLC

Dr. Hendifar Discusses Belzutifan in PNET + PPGL + VHL


Merck is sponsoring a phase 2 trial for those with pheochromocytoma/paraganglioma (PPGL) or Pancreatic Neuroendocrine Tumor (pNET), or Von Hippel-Lindau (VHL) who have progressed in the past 12 months. Those with pNET must have experienced disease progression on or after at least 1 line of prior systemic therapy that includes an approved targeted agent such as everolimus or sunitinib. Belzutifan is a daily, oral medication currently approved for the treatment of von Hippel–Lindau disease-associated renal cell carcinoma. 

For more information on eligibility criteria, trial locations, study details, etc., go to to view this trial here.


Merck Sharp & Dohme LLC


PHONE: 1-888-577-8839


This is a multicenter trial with various locations. Go to the “Contacts and Locations” section of this trial page at for site-specific contact information. 

bottom of page